Factors Determining Drug Residence in Skin during Transdermal Absorption: Studies on .BETA.-Blocking Agents.
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چکیده
منابع مشابه
Clinical Studies Role of Cardiac Factors in the Initial Hypotensive Action by Beta-Adrenoreceptor Blocking Agents
The blood pressure decrease after beta-blockade is delayed and there are little data on the hemodynamic events associated with the initial decrease in blood pressure. The present study measured the hemodynamics of the initial hypotensive action of timolol maleate, a nonselective betaadrenoreceptor blocking agent, in 10 patients with essential hypertension. Frequent measurements were made for th...
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Cardiac dysfunction in heart failure is widely recognized as a progressive process, regardless of the clinical signs and symptoms. An increase in cardiac sympathetic drive is one of the earliest neurohormonal responses occurring in patients with heart failure and may be one of the major causes of the progressive remodeling leading to the decline in myocardial function, and responsible for the p...
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Human skin serves a protective function by imposing physicochemical limitations to the type of permeant that can traverse the barrier. For a drug to be delivered passively via the skin it needs to have a suitable lipophilicity and a molecular weight < 500 Da. The number of commercially available products based on transdermal or dermal delivery has been limited by these requirements. In recent y...
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1 School of pharmacy and emerging sciences, Baddi University of Emerging Sciences and Technology, Makhnumajra Baddi. Distt Solan, H.P., India. 2 School of pharmacy and emerging sciences, Baddi University of Emerging Sciences and Technology, Makhnumajra Baddi. Distt Solan, H.P., India. 3 School of pharmacy and emerging sciences, Baddi University of Emerging Sciences and Technology, Makhnumajra B...
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OF THE MANY beta-receptor blocking agents developed over the past two decades only one, dl-propranolol, has become generally available to American physicians. However, as experience accumulates regarding the safety and efficacy of other beta-blockers, it is likely that at least some of these drugs (many of which are widely used in Europe) will gain approval for use in the United States. Thus an...
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ژورنال
عنوان ژورنال: Biological and Pharmaceutical Bulletin
سال: 1998
ISSN: 0918-6158,1347-5215
DOI: 10.1248/bpb.21.1195